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2 edition of Dopamine receptor subtype involvement in the behavioural effects of cocaine found in the catalog.

Dopamine receptor subtype involvement in the behavioural effects of cocaine

Rino Michelangelo Costanza

Dopamine receptor subtype involvement in the behavioural effects of cocaine

by Rino Michelangelo Costanza

  • 233 Want to read
  • 31 Currently reading

Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (Ph.D) - University of Birmingham, School of Psychology, Faculty of Science, 2000.

Statementby Rino Michelangelo Costanza.
ID Numbers
Open LibraryOL18794720M

Multiple subtypes of dopamine receptors exist in the brain. This volume reviews the characteristics of D-1, D-2, D-3 and D-4 receptors and describes the current concepts of their involvement in motor disorders and in the control of schizophrenia. Readers: the book will be of great interest to professionals in pharmacology, medicinal chemistry, neuroscience, cell . Normally, dopamine is then recycled back into the transmitting neuron by a specialized protein called the dopamine transporter. If cocaine is present, it attaches to the dopamine transporter and blocks the normal recycling process, resulting in a buildup of dopamine in the synapse, which contributes to the pleasurable effects of cocaine.

Dopamine is a neurotransmitter that plays a role in pleasure, motivation, and learning. It’s also linked to some major diseases. Here’s what you should know.   Since acetaldehyde directly stimulates dopamine neuronal firing in the mesolimbic system, the aim of this study was the investigation of dopamine D2-receptors' role in the onset of the operant drinking behaviour for acetaldehyde in different functional stages, by the administration of two different D2-receptor agonists, quinpirole and ropinirole.

Evidence suggests that stimulants such asd-amphetamine and cocaine act presynaptically by increasing the amount of dopamine (DA) available to stimulate postsynaptic DA receptors. Since two subpopulations of DA receptors (D1 and D2) exist, we investigated the role of both of these receptor subtypes in mediating the internal “state” produced by these stimulants. To assess the effects of chronic cocaine intoxication on dopamine receptors in human subjects, the authors evaluated [18F]N- methylspiroperidol binding using positron emission tomography in 10 cocaine abusers and 10 normal control subjects.


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Dopamine receptor subtype involvement in the behavioural effects of cocaine by Rino Michelangelo Costanza Download PDF EPUB FB2

Dopamine (DA) D3 and D2 receptor mechanisms are implicated in cocaine's abuse-related behavioral effects, but the relative contribution of the two receptor subtypes is only partially characterized. This study investigated the role of D3 and D2 subtype mechanisms by determining the degree to which the D3-preferring antagonist PG [ N -{4-[4-(2,3.

Dopamine receptors control neural signaling that modulates many important behaviors, such as spatial working memory. Dopamine also plays an important role in the reward system, incentive salience, cognition, prolactin release, emesis and motor function. Non-CNS dopamine receptors Cardio-pulmonary system.

In humans, the pulmonary artery expresses D 1, D 2, D 4, and D 5 and receptor subtypes. Abstract. The relationship between the behavioural effects of cocaine and the increase in dopamine caused by its blockade of dopamine re-uptake has been a major focus of research.

The relationship between the behavioural effects of cocaine and the increase in dopamine caused by its blockade of dopamine re-uptake has been a major focus of research interest. However, little is known regarding the involvement of recently cloned dopamine D2-like receptor subtypes (D2, D3 and D4) in different cocaine induced by: 1.

Abstract. The neurotransmitter dopamine mediates various behavioral functions in the central nervous system (CNS). The major dopamine pathway involved in motor function is the nigrostriatal pathway, which originates from the substantia nigra and is the primary source of dopaminergic innervation of the dorsal striatal neurons (1–4).It plays an important role in Cited by: 7.

Cocaine is a highly addictive drug of abuse whose addictive liability arises from its capacity to function as a powerful reinforcer (reward). This behavioral effect is dependent on its capacity to function as an indirect agonist of dopamine, resulting in enhanced stimulation of dopamine receptors, including the dopamine D3 subtype of receptor.

1 INTRODUCTION. Centrally acting drugs occasionally cause pronounced age‐dependent behavioral effects in rats and mice (Spear,).One of the most notable examples is the peptide‐coupling agent, N‐ethoxycarbonyl‐2‐ethoxy‐1,2‐dihydroquinoline (EEDQ), which irreversibly inactivates dopamine (DA) D1 and D2 receptors, among other receptor.

Role of dopamine D3 receptor in alleviating behavioural deficits in animal models of post-traumatic stress disorder Long-term behavioural effects of YQA14 after SPS in rats were analyzed by one-way analysis of variance.

E.L. Gardner, J. Li, Z.X. XiBlockade of D3 receptors by YQA14 inhibits cocaine's rewarding effects and relapse to drug. Dopamine receptor expression and distribution dynamically change in the rat nucleus accumbens after withdrawal from cocaine self-administration.

Neuroscience– /cience [PMC free article] Cools R. Role of dopamine in the motivational and cognitive control of behavior. Dopamine receptors play a critical role in reward-related learning, but receptor subtypes may be differentially involved.

D2-preferring receptor antagonists, e.g., haloperidol, attenuate acquisition of cocaine-conditioned motor activity at doses that fail to block expression. We compared haloperidol [4-[4-(4-chlorophenyl)hydroxypiperidyl](4-fluorophenyl)-butan-1.

A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain. | Explore the latest full-text research PDFs, articles, conference papers, preprints and more on. Although dopamine D 3 receptors have been associated with cocaine abuse, little is known about the consequences of chronic cocaine on functional activity of D 3 receptor-preferring compounds.

This study examined the behavioral effects of D 3 receptor-selective 4-phenylpiperazines with differing in vitro functional profiles in adult male rhesus monkeys with a history of cocaine.

This superior profile is believed to be secondary to its serotonin 5-HT2 antagonist properties, which may ameliorate the negative symptoms and affect the dopamine receptors in such a way as to reduce the incidence of extrapyramidal symptoms.

Cocaine. Many researchers are investigating the role that dopamine receptors may play in substance abuse. Background: Molecules critically involved in cocaine behavioral plasticity are known to regulate and interact with peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α).

In addition, the PGC-1α promoter has binding sites for early growth response 3 (Egr3), which plays a dynamic role in cocaine action in nucleus accumbens (NAc) medium spiny neuron (MSN) subtypes.

Abstract. With the advent of subtype-selective ligands and dopamine receptor knockout mice, the last two decades have seen an explosion in research on the role of dopamine receptor subtypes in reward and relapse to drug-seeking behavior. The dopamine D5 receptor (D5R) is a Gαs-coupled dopamine receptor belonging to the dopamine D1-like receptor family.

Together with the dopamine D2 receptor it is highly expressed in striatal. G-protein coupled receptor super family.

The dopamine receptor subtypes are divided into two major subclasses: types 1 and 5 are similar in structure and drug sensitivity, and these two receptors are referred to as the "D1like" group or class of receptors.

Dopamine receptor types 2, 3, and 4 are called the "D2like" group. Dopamine plays. The amygdala contains receptors for dopamine, a neurotransmitter involved in reward seeking, and has been shown to influence cocaine reward behaviors, making it a target for addiction treatment.

Dopamine receptors control neural signaling that modulates many important behaviors, such as spatial working memory. Non-CNS dopamine receptors Edit Cardio-pulmonary system Edit. In humans, the pulmonary artery expresses D1, D2, D4, and D5 and receptor subtypes, which may account for vasorelaxive effects of dopamine in the blood.

Dopamine receptor subtypes have been classified generally as D1-like (e.g., D1, D5) or D2-like (D2, D3, D4), and converging evidence suggests that D2-like receptors may be especially important in mediating the abuse-related effects of cocaine.

However, it has been difficult to differentiate the roles of the D2-like receptor subtypes in the. A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects.

D1-class receptor genes lack INTRONS, | Explore the latest full-text research PDFs.While there has been less evidence for a role of D 4 receptors in reinforcing effects of cocaine and, more generally, substance use disorders (Le Foll et al.

), polymorphisms in the D 4 receptor have been linked to novelty seeking (Laucht et al. ; Lusher et al. ), a personality trait associated with an increased risk of substance abuse. Centonze D, Grande C, Usiello A, Gubellini P, Erbs E, Martin AB, et al. Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons.

J Neurosci.